In vitro ADME and PK

ADME and Pharmacokinetic Services

Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis

Highly reproducible, accurate data - validated and used by over 1700 clients from the pharmaceutical, biotechnology, agrochemical, tobacco, cosmetics, health care companies and academic and government organisations.
Delivery of data for core in vitro ADME screening and physicochemical assays is within 10 working days to fit in with the make-test timelines in drug discovery. A number of different reporting options are available.
Highly cost effective due to our emphasis on high throughput engineering for key in vitro screening assays.
Attention to good quality customer care, with highly trained Principal Scientists on hand to explain results and suggest the most appropriate experimental strategy.
Flexibility - studies can be tailored to our customers’ specific requirements.
Regulations - our ADME services maintain and comply with regulatory guidelines providing constant confidence in the data.

Our facility has passed evaluations by a range of different organisations and companies from a variety of differing industries, including government agencies: All now routinely use our services to provide support to their programs.

ADME and PK Services

In Vitro Metabolism
Cytochrome P450 and UGT Reaction Phenotyping
Cytochrome P450 Induction
Cytochrome P450 Induction: Relative Induction Score
Cytochrome P450 Inhibition
Cytochrome P450 K_i
Hepatocyte Stability
Low Clearance HµREL Co-culture Assay
Low Clearance Hepatocyte Stability
Hepatic Uptake
Metabolite Profiling and Identification
Microsomal Binding
Microsomal Stability
Plasma Stability
PXR and AhR Nuclear Receptor Activation
S9 Stability
Time Dependent Inhibition (IC₅₀ Shift)
Time Dependent Inhibition (k_inact/K_I )
Time Dependent Inhibition (single point)
UGT Inhibition

In Vitro Permeability and Transporters
PAMPA
Caco-2 Permeability
MDCK-MDR1 Permeability
P-gp Substrate Identification
BCRP Substrate Identification
Human SLC Transporter Substrate Identification (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
Human MRP Transporter Substrate Identification
Preclinical Hepatic Oatp Uptake Transporter Substrate Identification (Rat Oatp1b2, Dog Oatp1b4 and Cynomolgus Monkey Oatp1b1)
P-gp Inhibition
BCRP Inhibition
Human SLC Transporter Inhibition (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
BSEP and MRP Inhibition
Preclinical Hepatic Oatp Uptake Transporter Inhibition (Rat Oatp1b2, Dog Oatp1b4 and Cynomolgus Monkey Oatp1b1)

Polymorphic and Non-CYP Mediated Metabolism
Monoamine Oxidase Inhibition
Monoamine Oxidase Reaction Phenotyping
Carboxylesterase Inhibition
Carboxylesterase Reaction Phenotyping
Aldehyde Oxidase Reaction Phenotyping